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Basically every human being alive (except if you have an allergy to certain medications) engages in this pharmaceutical debate far too often. It’s a question you hear in your office, your home, and often in your own head: which is better, ibuprofen or acetaminophen?

How well do you know two of the most popular pain relievers out there? You may not be taking the right pill for the right problem. Interestingly, docs advise alternating between ibuprofen and acetaminophen to minimize the risks and maximize the benefits. But don’t overuse them; they can be potent and can even make you sick if you take too many. Always take the smallest effective dose for the shortest window of time possible. (And, obviously, this is not a substitute for medical advice — always go see your doctor if you experience any sort of long-term pain or have questions about how to manage it.)

Take our quiz, below, to make sure you’re medicating your body properly.

(The white pill is acetaminophen, and the orange pill is ibuprofen.)