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With the dawn of a new CSI on the horizon (this time, CSI: Cyber starring Oscar winner Patricia Arquette), it seems only fitting that CBS has declared Wednesday World CSI Day. On this forensics-filled day, CBS is attempting to break the world record for “Largest Ever TV Drama Simulcast” by airing a special CSI episode, “Kitty,” in more than 150 countries, including Canada on E! at 7 p.m. ET. (It will also be streamed on CTV.ca from 7 p.m. ET – 3 a.m. ET.)

The CSI franchise has hit many milestones over the years and welcomed hundreds of special guest stars — some of which weren’t quite the big names way back then. From current series CSI and Cyber and fondly remembered installments CSI: Miami and CSI: NY  here are some of the more memorable stars who dropped in to make the procedurals even better.