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For as long as we can remember, we’ve somehow known that artificial sweeteners are bad for our health. Many of us tend to shy away from artificial sweeteners… except for maybe in diet sodas. But how bad could artificial sweeteners really be for us? After all, there aren’t any calories in them, whereas natural sugars do have calories, so artificial sweeteners at least have one good point, right?

Here’s a bit of a reality check for you: artificial sweeteners really mess with your brain–and not in a good way. We gathered up some research to show you exactly how your brain acts when it comes face to face with an artificial sweetener.

We’re sorry in advance for ruining your love for–or adding to your hatred of–artificial sweeteners, but it’s for the best.